Thoracoscopic Talc Insufflation Versus Talc Slurry in Patients with Malignant Pleural Effusion

Phase III intergroup study of talc poudrage vs talc slurry sclerosis for malignant pleural effusion.

STUDY OBJECTIVE To demonstrate the efficacy, safety, and appropriate mode of instillation of talc for sclerosis in treatment of malignant pleural effusions (MPEs). DESIGN A prospective, randomized trial was designed to compare thoracoscopy with talc insufflation (TTI) to thoracostomy and talc slurry (TS) for patients with documented MPE. MEASUREMENTS The primary end point was 30-day freedom...

Local iodine pleurodesis versus thoracoscopic talc insufflation in recurrent malignant pleural effusion: a prospective randomized control trial.

OBJECTIVE To compare the efficacy, safety, and outcome of thoracoscopic talc poudrage (TTP) versus povidone-iodine pleurodesis (PIP) through a thoracostomy tube as a palliative treatment of pleural effusion due to metastatic breast carcinoma (MBC). METHODS A total of 42 MBC patients were prospectively enrolled in a randomized controlled trial. Twenty-two patients received TTP (group A), where...

Review: thoracoscopic pleurodesis with talc may be the optimal technique in patients with malignant pleural effusions.

M e t h o d s Data sources: Cochrane Controlled Trials Register (Issue 4, 2001), MEDLINE (1980 to June 2002), EMBASE/Excerpta Medica (1980 to May 2002), bibliographies of relevant studies, and contacting experts. Study selection and assessment: Randomized controlled trials (RCTs) in any language of patients > 16 years of age having pleurodesis for pleural effusion in the context of metastatic c...

Pleurodesis for malignant pleural effusion: talc, toxicity and where next?

Treatment of recurrent malignant pleural effusion by iodized talc pleurodesis.

Chemical pleurodesis using iodized talc is an effective method of treating symptomatic recurrent malignant pleural effusions. Twenty-three effusions occurring in 21 patients treated by this method are described with two illustrative case reports. The procedure eliminated the need for further chest aspiration in all but one instance. The histological appearances of the pleura at intervals after ...